The importance of Ca2+-dependent mechanisms for the initiation of the heartbeat.
Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane (‘membrane clock’) and others to uptake and release of calcium from the sarcoplasmic reticulum (‘calcium clock’). Here we discuss recent evide...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00080/full |