Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3. This proapoptotic activity has been proposed to confer a tumor suppressor activity to this classic tyrosine ki...

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Bibliographic Details
Main Authors: Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasure
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2002912

Internet

https://doi.org/10.1371/journal.pbio.2002912

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