Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity

Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity

Repeat expansion mutations in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG translation of this expansion produces dipeptide repeat proteins (DRPs). The arginine containing DRPs, polyGR and polyP...

Full description

Bibliographic Details
Main Authors: Alan S. Premasiri, Anna L. Gill, Fernando G. Vieira
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
ALS (Amyotrophic lateral sclerosis)
FTD (Fronto-Temporal Dementia)
C9ORF72 DPRs
arginine methylation
protein arginine methyl transferase
glycine-arginine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.569661/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.569661/full

Similar Items