Synthesis, structure combined with conformational analysis, biological activities and docking studies of bis benzylidene cyclohexanone derivatives

Synthesis, structure combined with conformational analysis, biological activities and docking studies of bis benzylidene cyclohexanone derivatives

We report the synthesis and biological evaluation of bis benzylidne cyclohexanone derivatives 2,6-di(4-fluorobenzylidene)cyclohexanone 3a and (2E,6E)‐2,6‐bis({[4‐(trifluoromethyl)phenyl]methylidene})cyclohexanone 3b. Compound 3b crystallized in the monoclinic space group P21/n with unit cell paramet...

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Bibliographic Details
Main Authors: Gehad Lotfy, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Yasmine M. Abdel Aziz, Saied M. Soliman, Assem Barakat
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Saudi Chemical Society
Subjects:
Chalcones
α-Glucosidase inhibition
Antileishmanial
L. major promastigotes OpenEye
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610317300534

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http://www.sciencedirect.com/science/article/pii/S1319610317300534

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