Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex

Macrophage cytokine production is regulated by neural signals, for example in the inflammatory reflex. Signals in the vagus and splenic nerves are relayed by choline acetyltransferase+ T cells that release acetylcholine, the cognate ligand for alpha7 nicotinic acetylcholine subunit-containing recept...

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Bibliographic Details
Main Authors: Laura Tarnawski, Colin Reardon, April S. Caravaca, Mauricio Rosas-Ballina, Michael W. Tusche, Anna R. Drake, LaQueta K. Hudson, William M. Hanes, Jian Hua Li, William R. Parrish, Kaie Ojamaa, Yousef Al-Abed, Michael Faltys, Valentin A. Pavlov, Ulf Andersson, Sangeeta S. Chavan, Yaakov A. Levine, Tak W. Mak, Kevin J. Tracey, Peder S. Olofsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
inflammatory reflex
choline acetyltransferase
acetylcholine
adenylyl cyclase 6
sustained TNF inhibition
vagus nerve stimulation/VNS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02648/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02648/full

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