Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation.

Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation.

Box C/D-type small nucleolar RNAs (snoRNAs) are functional RNAs responsible for mediating 2'-O-ribose methylation of ribosomal RNAs (rRNAs) within the nucleolus. In the past years, evidence for the involvement of human U50 snoRNA in tumorigenesis has been accumulating. We previously identified...

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Bibliographic Details
Main Authors: Yuuichi Soeno, Kazuya Fujita, Tomoo Kudo, Masataka Asagiri, Shigeru Kakuta, Yuji Taya, Yoshihito Shimazu, Kaori Sato, Ritsuko Tanaka-Fujita, Sachiko Kubo, Yoichiro Iwakura, Yoshikazu Nakamura, Shigeo Mori, Takaaki Aoba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3753356?pdf=render

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http://europepmc.org/articles/PMC3753356?pdf=render

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