Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma

Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma

Abstract Background Hepatitis B virus (HBV) is the major risk factor for hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV-associated HCC pathogenesis is still unclear. Genetic alterations in cancer-related genes have been linked to many human cancers. Here, we aimed to explore...

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Bibliographic Details
Main Authors: Fung-Yu Huang, Danny Ka-Ho Wong, Vivien Wai-Man Tsui, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Keane K.-Y. Lai, Man-Fung Yuen
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Targeted sequencing
Deleterious mutations
Customized therapies
Gene silencing
Online Access:http://link.springer.com/article/10.1186/s12885-019-6002-9

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http://link.springer.com/article/10.1186/s12885-019-6002-9

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