Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Two strategies for the synthesis of the ATP (adenosine triphosphate) analogue ApppI [1-adenosin-5’-yl 3-(3-methylbut-3-enyl)triphosphoric acid diester] (1) are described. ApppI is an active metabolite of the mevalonate pathway and thus is of major biological significance. Chemically synthezised Appp...

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Bibliographic Details
Main Authors: Janne Weisell, Jouko Vepsäläinen, Petri A. Turhanen
Format: Article
Language:English
Published: Beilstein-Institut 2015-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
ApppI
ATP analogue
HPLC
purification
synthesis
Online Access:https://doi.org/10.3762/bjoc.11.237

Internet

https://doi.org/10.3762/bjoc.11.237

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