Transcriptional and post-transcriptional regulation of SPAST, the gene most frequently mutated in hereditary spastic paraplegia.

Transcriptional and post-transcriptional regulation of SPAST, the gene most frequently mutated in hereditary spastic paraplegia.

Hereditary spastic paraplegias (HSPs) comprise a group of neurodegenerative disorders that are characterized by progressive spasticity of the lower extremities, due to axonal degeneration in the corticospinal motor tracts. HSPs are genetically heterogeneous and show autosomal dominant inheritance in...

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Bibliographic Details
Main Authors: Brian J Henson, Wan Zhu, Kelsey Hardaway, Jaime L Wetzel, Mihaela Stefan, Kathryn M Albers, Robert D Nicholls
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3344893?pdf=render

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http://europepmc.org/articles/PMC3344893?pdf=render

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