Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Abstract Background Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there is generation of an anti-tumoral immune response. However, CRT has also been shown to promote immunosuppressive mechanisms which...

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Bibliographic Details
Main Authors: Aurelie Hanoteau, Jared M. Newton, Rosemarie Krupar, Chen Huang, Hsuan-Chen Liu, Angelina Gaspero, Robyn D. Gartrell, Yvonne M. Saenger, Thomas D. Hart, Saskia J. Santegoets, Damya Laoui, Chad Spanos, Falguni Parikh, Padmini Jayaraman, Bing Zhang, Sjoerd H. Van der Burg, Jo A. Van Ginderachter, Cornelis J. M. Melief, Andrew G. Sikora
Format: Article
Language:English
Published: BMJ Publishing Group 2019-01-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Immunotherapy
Tumor microenvironment
Inducible nitric oxide synthase (iNOS)
Cyclophosphamide
L-n6-(1-iminoethyl)-lysine (L-NIL)
Chemoradiotherapy
Online Access:http://link.springer.com/article/10.1186/s40425-018-0485-9

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http://link.springer.com/article/10.1186/s40425-018-0485-9

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