A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020

A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020

CRISPR effector proteins introduce double-stranded breaks into the mammalian genome, facilitating gene editing by non-homologous end-joining or homology-directed repair. Unlike the more commonly studied Cas9, the CRISPR effector protein Cas12a/Cpf1 recognizes a T-rich protospacer adjacent motif (PAM...

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Bibliographic Details
Main Authors: Mai H. Tran, Hajeung Park, Christopher L. Nobles, Pabalu Karunadharma, Li Pan, Guocai Zhong, Haimin Wang, Wenhui He, Tianling Ou, Gogce Crynen, Kelly Sheptack, Ian Stiskin, Huihui Mou, Michael Farzan
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
CRISPR
Cas12a
genome editing
protein engineering
Lb2Cas12a
hemophilia
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000470

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http://www.sciencedirect.com/science/article/pii/S2162253121000470

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