The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.

Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypothe...

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Bibliographic Details
Main Authors: Susan M L Banks, Bomsoo Cho, Suk Ho Eun, Ji-Hoon Lee, Sarah L Windler, Xuanhua Xie, David Bilder, Janice A Fischer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3063240?pdf=render

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http://europepmc.org/articles/PMC3063240?pdf=render

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