Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells

Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells

Abstract Background The Warburg effect demonstrates the importance of glycolysis in the development of primary and metastatic cancers. We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential transporters of lactate, in renal cancer progression during cancer-endot...

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Bibliographic Details
Main Authors: Chen Guo, Tao Huang, Qing-Hai Wang, Hong Li, Aashish Khanal, En-Hao Kang, Wei Zhang, Hai-Tao Niu, Zhen Dong, Yan-Wei Cao
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cancer Cell International
Subjects:
Monocarboxylate transporter
Glycolytic metabolism
Renal cell carcinoma
Cancer-endothelial microenvironment
Cancer invasion
Cancer metastasis
Online Access:http://link.springer.com/article/10.1186/s12935-019-0889-8

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http://link.springer.com/article/10.1186/s12935-019-0889-8

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