Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study

Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study

Background: Topical diclofenac, a nonsteroidal anti-inflammatory drug, has proven efficacy and safety in the management of osteoarthritis pain. We investigated penetration of topical diclofenac into knee synovial tissue and fluid (primary objective) and evaluated relative exposure in the knee versus...

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Bibliographic Details
Main Authors: Lothar Seefried, Mark Blyth, Rohit Maheshwari, Stephen M. McDonnell, Guillaume Frappin, Martina Hagen, Nadine Maybaum, Sebastian Moreira, Hemant Pandit
Format: Article
Language:English
Published: SAGE Publishing 2020-08-01
Series:Therapeutic Advances in Musculoskeletal Disease
Online Access:https://doi.org/10.1177/1759720X20943088

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https://doi.org/10.1177/1759720X20943088

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