In Vivo Priming of Peritoneal Tumor-Reactive Lymphocytes With a Potent Oncolytic Virus for Adoptive Cell Therapy

In Vivo Priming of Peritoneal Tumor-Reactive Lymphocytes With a Potent Oncolytic Virus for Adoptive Cell Therapy

Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes (TIL) achieves durable clinical benefit for patients from whom these cells can be derived in advanced metastatic melanoma but is limited in most solid tumors as a result of immune escape and exclusion. A tumor microenvironme...

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Bibliographic Details
Main Authors: Esther Giehl, Hiromichi Kosaka, Zuqiang Liu, Mathilde Feist, Udai S. Kammula, Michael T. Lotze, Congrong Ma, Zong Sheng Guo, David L. Bartlett
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
oncolytic virus
CD8+ T cells
IL-15
adoptive cell therapy (ACT)
solid tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.610042/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.610042/full

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