Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus

A possible etiological link between the onset of endemic pemphigus in Tunisia and bites of Phlebotomus papatasi, the vector of zoonotic cutaneous leishmaniasis, has been previously suggested. We hypothesized that the immunodominant P. papatasi salivary protein PpSP32 binds to desmogleins 1 and 3 (Ds...

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Main Authors: Soumaya Marzouki, Ines Zaraa, Maha Abdeladhim, Chaouki Benabdesselem, Fabiano Oliveira, Shaden Kamhawi, Mourad Mokni, Hechmi Louzir, Jesus G. Valenzuela, Melika Ben Ahmed
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-12-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.123861