Experimental validation of multi-epitope peptides including promising MHC class I- and class II-restricted epitopes of four known Leishmania infantum proteins

Experimental validation of multi-epitope peptides including promising MHC class I- and class II-restricted epitopes of four known Leishmania infantum proteins

Leishmaniasis is a significant worldwide health problem for which no vaccine exists. Activation of CD4+ and CD8+ T cells is crucial for the generation of protective immunity against parasite. Recent trend in vaccine design has been shifted to epitope-based vaccines that are more specific, safe, and...

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Bibliographic Details
Main Authors: Maria eAgallou, Evita eAthanasiou, Olga eKoutsoni, Eleni eDotsika, Evdokia eKaragouni
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Immunology
Subjects:
Histone H1
lymphocyte proliferation
in silico analysis
cysteine peptidase A
kinetoplastid membrane protein 11
Leishmania eukaryotic initiation factor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00268/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00268/full

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