Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

IL-1β, a pro-inflammatory cytokine, has been shown to contribute to radiation injury. Sirt1, an NAD+-dependent class III protein deacetylase, plays an important role in the regulation of the proinflammatory cytokines involved in inflammation-associated diseases. The relationship between Sirt1 and IL...

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Bibliographic Details
Main Authors: Feiyue Fan, Qiang Liu, Saijun Fan, Xu Su, Jianxiang Liu, Jia Cao, Tiqiang Fan, Chang Xu, Liqing Du, Yan Wang, Yue Fu
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:International Journal of Molecular Sciences
Subjects:
radiation
IL-1β
SIRT1
NLRP3
resveratrol
Online Access:http://www.mdpi.com/1422-0067/14/7/14105

Internet

http://www.mdpi.com/1422-0067/14/7/14105

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