Identification of a Novel HIF-1α-αMβ2 Integrin-NET Axis in Fibrotic Interstitial Lung Disease

Identification of a Novel HIF-1α-αMβ2 Integrin-NET Axis in Fibrotic Interstitial Lung Disease

Neutrophilic inflammation correlates with mortality in fibrotic interstitial lung disease (ILD) particularly in the most severe form, idiopathic pulmonary fibrosis (IPF), although the underlying mechanisms remain unclear. Neutrophil function is modulated by numerous factors, including integrin activ...

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Bibliographic Details
Main Authors: Akif A. Khawaja, Deborah L. W. Chong, Jagdeep Sahota, Theresia A. Mikolasch, Charis Pericleous, Vera M. Ripoll, Helen L. Booth, Saif Khan, Manuel Rodriguez-Justo, Ian P. Giles, Joanna C. Porter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
neutrophil
NET
hypoxia
HIF
endothelium
integrin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02190/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.02190/full

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