Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers

Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers

Abstract Background Wilson disease (WD) is an autosomal recessive disease caused by mutations in ATP7B encoding a copper transporter. Consequent copper accumulation results in a variable WD clinical phenotype involving hepatic, neurologic, and psychiatric symptoms, without clear genotype–phenotype c...

Full description

Bibliographic Details
Main Authors: Charles E. Mordaunt, Dorothy A. Kieffer, Noreene M. Shibata, Anna Członkowska, Tomasz Litwin, Karl-Heinz Weiss, Yihui Zhu, Christopher L. Bowlus, Souvik Sarkar, Stewart Cooper, Yu-Jui Yvonne Wan, Mohamed R. Ali, Janine M. LaSalle, Valentina Medici
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Epigenetics & Chromatin
Subjects:
Wilson disease
Epigenetics
Copper
DNA methylation
Whole-genome bisulfite sequencing
Chromatin
Online Access:http://link.springer.com/article/10.1186/s13072-019-0255-z

Internet

http://link.springer.com/article/10.1186/s13072-019-0255-z

Similar Items