Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease

Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease

Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a deficient level of activity of glucocerebrosidase (GCase). This deficiency leads to the accumulation of the glycolipid glucocerebroside in the lysosomes of cells, mainly in the monocyte/macrophage line...

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Bibliographic Details
Main Authors: Constanza Bondar, Maximiliano Ormazabal, Andrea Crivaro, Malena Ferreyra-Compagnucci, María Victoria Delpino, Paula Adriana Rozenfeld, Juan Marcos Mucci
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
Gaucher disease
bone
osteocyte
osteoclast
apoptotic bodies
Online Access:http://www.mdpi.com/1422-0067/18/1/112

Internet

http://www.mdpi.com/1422-0067/18/1/112

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