Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.

Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.

The BRAFV600E mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAFV600E under elevated TSH levels induced thyroid cancers in several genetically engineered mouse models. In contrast, we found...

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Bibliographic Details
Main Authors: Mika Shimamura, Nobuyuki Shibusawa, Tomomi Kurashige, Zhanna Mussazhanova, Hiroki Matsuzaki, Masahiro Nakashima, Masanobu Yamada, Yuji Nagayama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6080762?pdf=render

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http://europepmc.org/articles/PMC6080762?pdf=render

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