Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate.

Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate.

The anti-malarial artesunate also exerts profound anti-cancer activity. The susceptibility of tumor cells to artesunate can be enhanced by ferrous iron. The transferrin receptor (TfR) is involved in iron uptake by internalization of transferrin and is over-expressed in rapidly growing tumors. The AT...

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Bibliographic Details
Main Authors: Gerhard Kelter, Daniel Steinbach, Venkata Badireenath Konkimalla, Tsuyoshi Tahara, Shigeru Taketani, Heinz-Herbert Fiebig, Thomas Efferth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1949049?pdf=render

Internet

http://europepmc.org/articles/PMC1949049?pdf=render

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