A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

Abstract Background The methylotrophic yeast Pichia pastoris is a well-studied host organism for recombinant protein production, which is usually regulated either by a constitutive promoter (e.g. promoter of glyceraldehyde-3-phosphate dehydrogenase; PGAP) or an inducible promoter (e.g. promoter of a...

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Bibliographic Details
Main Authors: Vignesh Rajamanickam, Karl Metzger, Christian Schmid, Oliver Spadiut
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Microbial Cell Factories
Subjects:
Pichia pastoris
Bi-directional promoter
Bioprocess development
Mixed feed
Tunable recombinant protein production
Online Access:http://link.springer.com/article/10.1186/s12934-017-0768-8

Internet

http://link.springer.com/article/10.1186/s12934-017-0768-8

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