CD4+CD25+CD127low regulatory T cells play predominant anti-tumor suppressive role in hepatitis B virus associated hepatocellular carcinoma

CD4+CD25+CD127low regulatory T cells play predominant anti-tumor suppressive role in hepatitis B virus associated hepatocellular carcinoma

Background:Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and hepatitis B is one of the commonest causes. T regulatory cells (Tregs) are strong immunomodulators and are likely to play a major role in HCC development. HBV infection is reported to induce expansion...

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Bibliographic Details
Main Authors: Shreya eSharma, Ritu eKhosla, Paul eDavid, Archana eRastogi, Ashish eVyas, Dileep eSingh, Ankit eBhardwaj, Amrish eSahney, Rakhi eMaiwall, Shiv Kumar Sarin, Nirupma eTrehanpati
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Immunology
Subjects:
Hepatitis B virus; (HBV)
TGF-β; Transforming growth factor- β
Tregs; T regulatory Cells
Hepatocellular Carcinoma; ( HCC)
AFP; Alpha-fetoprotein
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00049/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00049/full

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