Class II MHC self-antigen presentation in human B and T lymphocytes.

Human CD4(+) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound self-peptides presented by CD4(+) T cells in order to compare the T cell-der...

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Bibliographic Details
Main Authors: Cristina Maria Costantino, Eric Spooner, Hidde L Ploegh, David A Hafler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3267721?pdf=render