The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

Abstract Many cancers possess an incorrect number of chromosomes, a state described as aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is believed to endow tumours with enhanced evolutionary capabilities due to increase...

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Main Authors: Andréa E. Tijhuis, Sarah C. Johnson, Sarah E. McClelland
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Molecular Cytogenetics
Online Access:http://link.springer.com/article/10.1186/s13039-019-0429-1
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spelling doaj-51e07b647894455c91fc83d94fe3dc602020-11-25T02:56:40ZengBMCMolecular Cytogenetics1755-81662019-05-0112112110.1186/s13039-019-0429-1The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunityAndréa E. Tijhuis0Sarah C. Johnson1Sarah E. McClelland2Barts Cancer Institute, Queen Mary University of LondonBarts Cancer Institute, Queen Mary University of LondonBarts Cancer Institute, Queen Mary University of LondonAbstract Many cancers possess an incorrect number of chromosomes, a state described as aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is believed to endow tumours with enhanced evolutionary capabilities due to increased intratumour heterogeneity, and facilitating adaptive resistance to therapies. Recently, however, additional consequences and associations with CIN have been revealed, prompting the need to understand this universal hallmark of cancer in a multifaceted context. This review is focused on the investigation of possible links between CIN, metastasis and the host immune system in cancer development and treatment. We specifically focus on these links since most cancer deaths are due to the consequences of metastasis, and immunotherapy is a rapidly expanding novel avenue of cancer therapy.http://link.springer.com/article/10.1186/s13039-019-0429-1
collection DOAJ
language English
format Article
sources DOAJ
author Andréa E. Tijhuis
Sarah C. Johnson
Sarah E. McClelland
spellingShingle Andréa E. Tijhuis
Sarah C. Johnson
Sarah E. McClelland
The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
Molecular Cytogenetics
author_facet Andréa E. Tijhuis
Sarah C. Johnson
Sarah E. McClelland
author_sort Andréa E. Tijhuis
title The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
title_short The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
title_full The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
title_fullStr The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
title_full_unstemmed The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
title_sort emerging links between chromosomal instability (cin), metastasis, inflammation and tumour immunity
publisher BMC
series Molecular Cytogenetics
issn 1755-8166
publishDate 2019-05-01
description Abstract Many cancers possess an incorrect number of chromosomes, a state described as aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is believed to endow tumours with enhanced evolutionary capabilities due to increased intratumour heterogeneity, and facilitating adaptive resistance to therapies. Recently, however, additional consequences and associations with CIN have been revealed, prompting the need to understand this universal hallmark of cancer in a multifaceted context. This review is focused on the investigation of possible links between CIN, metastasis and the host immune system in cancer development and treatment. We specifically focus on these links since most cancer deaths are due to the consequences of metastasis, and immunotherapy is a rapidly expanding novel avenue of cancer therapy.
url http://link.springer.com/article/10.1186/s13039-019-0429-1
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