REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactiva...

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Main Authors:	Cristina Gontan, Hegias Mira-Bontenbal, Aristea Magaraki, Catherine Dupont, Tahsin Stefan Barakat, Eveline Rentmeester, Jeroen Demmers, Joost Gribnau
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07060-w

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spelling	doaj-51d821b56da94099bdacf7d9588827272021-05-11T10:18:25ZengNature Publishing GroupNature Communications2041-17232018-11-019111210.1038/s41467-018-07060-wREX1 is the critical target of RNF12 in imprinted X chromosome inactivation in miceCristina Gontan0Hegias Mira-Bontenbal1Aristea Magaraki2Catherine Dupont3Tahsin Stefan Barakat4Eveline Rentmeester5Jeroen Demmers6Joost Gribnau7Department of Developmental Biology, Oncode Institute, Erasmus MCDepartment of Developmental Biology, Oncode Institute, Erasmus MCDepartment of Developmental Biology, Oncode Institute, Erasmus MCDepartment of Developmental Biology, Oncode Institute, Erasmus MCDepartment of Developmental Biology, Oncode Institute, Erasmus MCDepartment of Developmental Biology, Oncode Institute, Erasmus MCCenter for Proteomics, Erasmus MCDepartment of Developmental Biology, Oncode Institute, Erasmus MCREX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactivation in mice.https://doi.org/10.1038/s41467-018-07060-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cristina Gontan Hegias Mira-Bontenbal Aristea Magaraki Catherine Dupont Tahsin Stefan Barakat Eveline Rentmeester Jeroen Demmers Joost Gribnau
spellingShingle	Cristina Gontan Hegias Mira-Bontenbal Aristea Magaraki Catherine Dupont Tahsin Stefan Barakat Eveline Rentmeester Jeroen Demmers Joost Gribnau REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice Nature Communications
author_facet	Cristina Gontan Hegias Mira-Bontenbal Aristea Magaraki Catherine Dupont Tahsin Stefan Barakat Eveline Rentmeester Jeroen Demmers Joost Gribnau
author_sort	Cristina Gontan
title	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_short	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_full	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_fullStr	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_full_unstemmed	REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
title_sort	rex1 is the critical target of rnf12 in imprinted x chromosome inactivation in mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-11-01
description	REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactivation in mice.
url	https://doi.org/10.1038/s41467-018-07060-w
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REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

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