REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactiva...

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Bibliographic Details
Main Authors: Cristina Gontan, Hegias Mira-Bontenbal, Aristea Magaraki, Catherine Dupont, Tahsin Stefan Barakat, Eveline Rentmeester, Jeroen Demmers, Joost Gribnau
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07060-w

Internet

https://doi.org/10.1038/s41467-018-07060-w

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