Liquid-phase oxidation of 2-chlorotoluene with ozone to 2-chlorobenzoic acid – an intermediate for diclofenac sodium production
2-Chlorobenzoic acid is used as an intermediate for diclofenac sodium production. In industry, it is obtained by oxidation of 2-chlorotoluene with potassium permanganate in an aqueous acidic medium. Due to the deficiency and cost of the oxidant as well as the formation of large amounts of toxic wast...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaporozhye State Medical University
2020-11-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| Subjects: | |
| Online Access: | http://pharmed.zsmu.edu.ua/article/view/216168/216795 |