Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges

Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges

Noroviruses, in the genus <i>Norovirus</i>, are a significant cause of viral gastroenteritis in humans and animals. For almost 50 years, the lack of a cultivation system for human noroviruses (HuNoVs) was a major barrier to understanding virus biology and the development of effective ant...

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Bibliographic Details
Main Authors: Mary K. Estes, Khalil Ettayebi, Victoria R. Tenge, Kosuke Murakami, Umesh Karandikar, Shih-Ching Lin, B. Vijayalakshmi Ayyar, Nicolas W. Cortes-Penfield, Kei Haga, Frederick H. Neill, Antone R. Opekun, James R. Broughman, Xi-Lei Zeng, Sarah E. Blutt, Sue E. Crawford, Sasirekha Ramani, David Y. Graham, Robert L. Atmar
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Viruses
Subjects:
human norovirus cultivation
intestinal enteroids/organoids
virus neutralization and inactivation
Online Access:https://www.mdpi.com/1999-4915/11/7/638

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https://www.mdpi.com/1999-4915/11/7/638

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