Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease

Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease

The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα p...

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Bibliographic Details
Main Authors: Jingling Jin, Leila Valanejad, Thuy Phuong Nguyen, Kyle Lewis, Mary Wright, Ashley Cast, Lauren Stock, Lubov Timchenko, Nikolai A. Timchenko
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Subjects:
cdk4
cyclin D3
NAFLD
p300
C/EBP
hepatic steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307598

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716307598

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