BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

The formation of Alzheimer's Aβ peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme β-secretase (BACE1); inhibition of this cleavage has been proposed as a means of treating Alzheimer's disease. (AD) We have previously shown that young BACE1 knockout mice...

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Bibliographic Details
Main Authors: Yi Luo, Brad Bolon, Michael A Damore, Dan Fitzpatrick, Hantao Liu, Jianhua Zhang, Qiao Yan, Robert Vassar, Martin Citron
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid
Aβ
β-Secretase
BACE
Knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001049

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http://www.sciencedirect.com/science/article/pii/S0969996103001049

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