Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4). Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reduct...

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Bibliographic Details
Main Authors: Youngah Jo, Steven S Kim, Kristina Garland, Iris Fuentes, Lisa M DiCarlo, Jessie L Ellis, Xueyan Fu, Sarah L Booth, Bret M Evers, Russell A DeBose-Boyd
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
isoprenoid
vitamin K
embryonic lethality
cholesterol
Online Access:https://elifesciences.org/articles/54841

Internet

https://elifesciences.org/articles/54841

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