Identification of Matrine as a Novel Regulator of the CXCR4 Signaling Axis in Tumor Cells

Identification of Matrine as a Novel Regulator of the CXCR4 Signaling Axis in Tumor Cells

Matrine, a quinolizidine alkaloid, is commonly employed for treating various viral and inflammatory disorders. Here, we have evaluated matrine for its activity on C-X-C chemokine receptor type 4 (CXCR4) and matrix metalloproteinases (MMP-9/2) expression, and its potential to affect tumor metastasis...

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Bibliographic Details
Main Authors: Young Yun Jung, Jae-Young Um, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Alan Prem Kumar, Kwang Seok Ahn
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
matrine
CXCR4
NF-ĸB
MMP-9/2
Online Access:https://www.mdpi.com/1422-0067/21/13/4731

Internet

https://www.mdpi.com/1422-0067/21/13/4731

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