Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation

Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation

Chromatin accessibility mapping is a powerful approach to identify potential regulatory elements. A popular example is ATAC-seq, whereby Tn5 transposase inserts sequencing adapters into accessible DNA (‘tagmentation’). CUT&Tag is a tagmentation-based epigenomic profiling method in which antibody...

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Bibliographic Details
Main Authors: Steven Henikoff, Jorja G Henikoff, Hatice S Kaya-Okur, Kami Ahmad
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
epigenomic profiling
chromatin accessibility
histone modifications
cut & tag
Online Access:https://elifesciences.org/articles/63274

Internet

https://elifesciences.org/articles/63274

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