Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

Complexes of specifically interacting molecules, such as transcription factor proteins (TFs) and the DNA response elements (REs) they recognize, control most biological processes, but little is known concerning the functional and evolutionary effects of epistatic interactions across molecular interf...

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Bibliographic Details
Main Authors: Dave W Anderson, Alesia N McKeown, Joseph W Thornton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
evolution
biochemistry
epistasis
sequence space
transcription factor
permissive mutation
Online Access:https://elifesciences.org/articles/07864

Internet

https://elifesciences.org/articles/07864

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