UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene

UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene

Apoptosis is an important defense mechanism mounted by the immune system to control virus replication. Hence, cytomegaloviruses (CMV) evolved and acquired numerous anti-apoptotic genes. The product of the human CMV (HCMV) UL36 gene, pUL36 (also known as vICA), binds to pro-caspase-8, thus inhibiting...

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Bibliographic Details
Main Authors: M. Zeeshan Chaudhry, Bahram Kasmapour, Carlos Plaza-Sirvent, Milica Bajagic, Rosaely Casalegno Garduño, Lisa Borkner, Tihana Lenac Roviš, Andrea Scrima, Stipan Jonjic, Ingo Schmitz, Luka Cicin-Sain
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cytomegalovirus
apoptosis
UL36
M36
Transgenic virus
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00312/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00312/full

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