Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

Quantitative measurement of intramolecular and intermolecular interactions in protein structure is an elusive task, not easy to address experimentally. The phenomenon denoted ‘energetic coupling’ describes short- and long-range interactions between two residues in a protein system. A powerful method...

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Bibliographic Details
Main Authors: Livia Pagano, Angelo Toto, Francesca Malagrinò, Lorenzo Visconti, Per Jemth, Stefano Gianni
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
coupling energy
site-directed mutagenesis
interaction networks
Online Access:https://www.mdpi.com/1422-0067/22/2/828

Internet

https://www.mdpi.com/1422-0067/22/2/828

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