Cholesterol Transport in Wild-Type NPC1 and P691S: Molecular Dynamics Simulations Reveal Changes in Dynamical Behavior

Cholesterol Transport in Wild-Type NPC1 and P691S: Molecular Dynamics Simulations Reveal Changes in Dynamical Behavior

The Niemann–Pick C1 (NPC1) protein is the main protein involved in NPC disease, a fatal lysosomal lipid storage disease. NPC1, containing 1278 amino acids, is comprised of three lumenal domains (N-terminal, middle lumenal, C-terminal) and a transmembrane (TM) domain that contains a five helix bundle...

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Bibliographic Details
Main Author: Nadia Elghobashi-Meinhardt
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann–Pick C1 (NPC) protein
cholesterol
P691 mutant
itraconazole binding site (IBS)
molecular dynamics (MD) simulations
Online Access:https://www.mdpi.com/1422-0067/21/8/2962

Internet

https://www.mdpi.com/1422-0067/21/8/2962

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