Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors

Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors

The transferrin (TfR) and epidermal growth factor receptors (EGFR) are known to be overexpressed on the surface of a wide variety of tumor cells. Therefore, the peptides B6 (TfR specific) and GE11 (targeted to the EGFR) were linked to the PAMAM (polyamidoamine) structure via a polyethylenglycol (PEG...

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Bibliographic Details
Main Authors: Koldo Urbiola, Laura Blanco-Fernández, Manfred Ogris, Wolfgang Rödl, Ernst Wagner, Conchita Tros de Ilarduya
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Journal of Personalized Medicine
Subjects:
nanotechnology
cancer
gene therapy
cationic polymers
polyethylenglycol
gene silencing
Online Access:http://www.mdpi.com/2075-4426/8/1/4

Internet

http://www.mdpi.com/2075-4426/8/1/4

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