Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy

Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy

Abstract Background Ubiquitination is a basic post-translational modification for cellular homeostasis, and members of the conjugating enzyme (E2) family are the key components of the ubiquitin–proteasome system. However, the role of E2 family in colorectal cancer (CRC) is largely unknown. Our study...

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Bibliographic Details
Main Authors: Tong Shen, Ling-Dong Cai, Yu-Hong Liu, Shi Li, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Peng-Da Guo, Qun Zhou, Xing-Xing Lu, Li-Na Sun, Jian-Ming Li
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Hematology & Oncology
Subjects:
Ubiquitin-conjugating E2 enzyme
Autophagy
Epithelial mesenchymal transition
Metastasis
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s13045-018-0638-9

Internet

http://link.springer.com/article/10.1186/s13045-018-0638-9

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