Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease
<p>Abstract</p> <p>Background</p> <p>Huntington's Disease (HD) is an inherited autosomal dominant genetic disorder in which neuronal tissue degenerates. The pathogenesis of the disease appears to center on the development of protein aggregates that arise initially...
Main Authors: | Parekh-Olmedo Hetal, Yerkes Sarah, Roth Jennifer, Skogen Michael, Kmiec Eric |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2006-10-01
|
Series: | BMC Neuroscience |
Online Access: | http://www.biomedcentral.com/1471-2202/7/65 |
Similar Items
-
G4 Matters—The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides
by: Carolina Roxo, et al.
Published: (2021-05-01) -
Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.
by: Niels H Skotte, et al.
Published: (2014-01-01) -
The Clinical Potential of Oligonucleotide Therapeutics against Pancreatic Cancer
by: Kazuki Takakura, et al.
Published: (2019-07-01) -
Recent Advances in Oligonucleotide Therapeutics in Oncology
by: Haoyu Xiong, et al.
Published: (2021-03-01) -
Data on secondary structures and ligand interactions of G-rich oligonucleotides that defy the classical formula for G4 motifs
by: Maria Vlasenok, et al.
Published: (2017-04-01)