Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

The integrity of epithelial and endothelial barriers in the lower airspaces of the lungs has to be tightly regulated, in order to prevent leakage and to assure efficient gas exchange between the alveoli and capillaries. Both G- and G+ bacterial toxins, such as LPS and pneumolysin, respectively, can...

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Bibliographic Details
Main Authors: Rudolf eLucas, Istvan eCzikora, Supriya eSridhar, Evgeny A Zemskov, Aluya eOseghale, Sebastian eCirco, Stephen D. Cederbaum, Trinad eChakraborty, David eFulton, Robert W. Caldwell, Maritza J. Romero
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
Pneumonia
pneumolysin
capillary leak
arginase 1
endothelial nitric oxide synthase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00228/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00228/full

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