Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity

Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity

Natural Killer Lytic-Associated Molecule (NKLAM), also designated RNF19B, is a unique member of a small family of E3 ubiquitin ligases. This 14-member group of ligases has a characteristic cysteine-rich RING-IBR-RING (RBR) domain that mediates the ubiquitination of multiple substrates. The consequen...

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Bibliographic Details
Main Authors: Donald W. Lawrence, Paul A. Willard, Allyson M. Cochran, Emily C. Matchett, Jacki Kornbluth
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
NKLAM
ubiquitin ligase
innate immunity
natural killer
macrophage
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.573372/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.573372/full

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