Defects in germinal center selection in SLE

Defects in germinal center selection in SLE

Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occurs. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and undergo somatic mutation before cycling back to th...

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Bibliographic Details
Main Authors: Megan eWoods, Yong-Rui eZou, Anne eDavidson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Germinal Center
B cell
SLE
tolerance mechanisms
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00425/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00425/full

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