Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly

Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly

The Senataxin (SETX) protein exhibits strong sequence conservation with the helicase domain of the yeast protein Sen1p, and recessive SETX mutations cause a severe ataxia, known as Ataxia with Oculomotor Apraxia type 2, while dominant SETX mutations cause Amyotrophic Lateral Sclerosis type 4. SETX i...

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Bibliographic Details
Main Authors: Craig L. Bennett, Bryce L. Sopher, Albert R. La Spada
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Heliyon
Subjects:
Cell biology
Genetics
Neuroscience
Infectious disease
Gene expression
Gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020310094

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http://www.sciencedirect.com/science/article/pii/S2405844020310094

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