Establishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells

Establishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells

Adenoviral viral vectors have been widely used for gene-based therapeutics, but commonly used serotype 5 shows poor transduction efficiency into hematopoietic cells. In this study, we aimed to generate a recombinant adenovirus serotype 5 (rAd5) vector that has a high efficiency in gene transfer to m...

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Bibliographic Details
Main Authors: Peng Xu, Xiaomei Wang, Yi Li, Jianming Qiu
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
parvovirus B19
adenoviral vector
cell cycle arrest
apoptosis
anti-cancer
Online Access:https://www.mdpi.com/1999-4915/11/9/820

Internet

https://www.mdpi.com/1999-4915/11/9/820

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