Real-Time Imaging Reveals Augmentation of Glutamate-Induced Ca2+ Transients by the NO-cGMP Pathway in Cerebellar Granule Neurons

Real-Time Imaging Reveals Augmentation of Glutamate-Induced Ca2+ Transients by the NO-cGMP Pathway in Cerebellar Granule Neurons

Dysfunctions of NO-cGMP signaling have been implicated in various neurological disorders. We have studied the potential crosstalk of cGMP and Ca2+ signaling in cerebellar granule neurons (CGNs) by simultaneous real-time imaging of these second messengers in living cells. The NO donor DEA/NO evoked c...

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Bibliographic Details
Main Authors: Michael Paolillo, Stefanie Peters, Andrea Schramm, Jens Schlossmann, Robert Feil
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
cyclic GMP
calcium
nitric oxide
guanylyl cyclase
cerebellar granule cells
protein kinase
PKG
FRET imaging
transgenic mice
Online Access:http://www.mdpi.com/1422-0067/19/8/2185

Internet

http://www.mdpi.com/1422-0067/19/8/2185

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