NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

The presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and promote cancer/stromal cells expansion, which can be r...

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Main Authors:	Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18919-2

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spelling	doaj-50d8fbca5759425c9fb107d5441047f82021-05-11T07:59:21ZengNature Publishing GroupNature Communications2041-17232020-10-0111111410.1038/s41467-020-18919-2NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skinAtul Katarkar0Giulia Bottoni1Andrea Clocchiatti2Sandro Goruppi3Pino Bordignon4Francesca Lazzaroni5Ilaria Gregnanin6Paola Ostano7Victor Neel8G. Paolo Dotto9Department of Biochemistry, University of LausanneCutaneous Biology Research Center, Massachusetts General HospitalCutaneous Biology Research Center, Massachusetts General HospitalCutaneous Biology Research Center, Massachusetts General HospitalDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneCancer Genomics Laboratory, Edo and Elvo Tempia Valenta FoundationCancer Genomics Laboratory, Edo and Elvo Tempia Valenta FoundationDepartment of Dermatology, Massachusetts General HospitalDepartment of Biochemistry, University of LausanneThe presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and promote cancer/stromal cells expansion, which can be reversed by NOTCH inhibition.https://doi.org/10.1038/s41467-020-18919-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Atul Katarkar Giulia Bottoni Andrea Clocchiatti Sandro Goruppi Pino Bordignon Francesca Lazzaroni Ilaria Gregnanin Paola Ostano Victor Neel G. Paolo Dotto
spellingShingle	Atul Katarkar Giulia Bottoni Andrea Clocchiatti Sandro Goruppi Pino Bordignon Francesca Lazzaroni Ilaria Gregnanin Paola Ostano Victor Neel G. Paolo Dotto NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin Nature Communications
author_facet	Atul Katarkar Giulia Bottoni Andrea Clocchiatti Sandro Goruppi Pino Bordignon Francesca Lazzaroni Ilaria Gregnanin Paola Ostano Victor Neel G. Paolo Dotto
author_sort	Atul Katarkar
title	NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin
title_short	NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin
title_full	NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin
title_fullStr	NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin
title_full_unstemmed	NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin
title_sort	notch1 gene amplification promotes expansion of cancer associated fibroblast populations in human skin
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	The presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and promote cancer/stromal cells expansion, which can be reversed by NOTCH inhibition.
url	https://doi.org/10.1038/s41467-020-18919-2
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NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

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